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These observations also highlight that therapeutic approaches should be directed at specific aspects of astrocyte reactivity, for example astrocyte Ccl2 production, rather than at attenuating reactivity per se, which may lead to unexpected and undesirable consequences

Safety and pharmacokinetics of bimagrumab in healthy older and obese adults with body composition changes in the older cohort

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Using its potent and selective MOR agonism to study the neuroadaptive changes that occur with repeated MOR stimulation, including receptor downregulation, desensitisation, and the neurobiological basis of opioid tolerance in pre-clinical models